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Dual agonism activates two hormone pathways, typically producing greater weight loss and glycemic benefit than single-target GLP-1 therapy in clinical trials

Community reports cluster around the same dominant findings as the trial injection-site reactions and brief joint pain in the first 2-4 weeks

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Tesamorelin is frequently examined in research involving growth hormone pathways, metabolic activity, body composition mechanisms, and peptide signaling

N Engl J Med 2021;385:1451-61

Tirzepatide seems to be the better option. The best weight loss results, according to the meta analysis, were with the highest doses of tirzepatide