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Drawing on the example of ADCs, continued progress in linker design, conjugation strategies, and supportive regulatory pathways is expected to facilitate the clinical approval of AOCs within the coming decade

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At the end of the analysis period, an intravenous bolus injection of the green-fluorescent bile salt analogue cholyl-lysyl-fluorescein (CLF) was performed as a positive control as it is known to be rapidly taken up into hepatocytes and excreted into bile canaliculi (Vartak et al