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The pharmacological mechanism of TCAs mainly involves its interaction with neurotransmitters in the brain, resulting in changes in neurotransmitter levels and an antidepressant effect

The melanin index recorded was the average of three readings

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This integrated approach helps identify essential pathways and molecular signatures associated with the condition, offering potential benefits in diagnosis and the design of targeted therapies

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Together, this shows that after acute damage FOXO4 favors senescence over apoptosis and maintains viability of senescent cells by repressing their apoptosis response