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Whereas overexpression of NAMPT in the adipose tissue leads to both a reduction in adiposity and a complete rescue of the sociability deficits, interventions that activate the pathways downstream of adipose tissue NAMPT, such as systemic NMN treatment or direct targeting of SIRT1 in the NAc, did not have an impact on body composition

The FDA is expected to decide on the Wegovy oral formulation NDA later this year.

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