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In general, for most patients, IV therapy takes 30-45 minutes from start to finish

++ For the ESRD and Aged/Disabled populations separately, if this difference is less (more negative) than 1.0 percentage point (for example, 1.5, 2.0, 3.0), CMS would recompute the ACO-specific ACPT value for the corresponding enrollment type(s) initially determined at proposed paragraph (b)(5) of 425.660

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In hypoxic tumor microenvironments, hypoxia inducible factor 1 subunit alpha (HIF1A, also known as HIF1) represses DLAT expression and confers resistance to cuproptosis 176 , supporting the existence of a HIF1A-DLAT-GSH regulatory axis

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