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Factors for extended use include continued tracking for GI tolerability, periodic assessment of heart parameters (heart rate, blood pressure), tracking for gallbladder disease (risk increases with rapid weight loss), and regular body assessments

For studies with multiple dose arms, only the highest dose was retained for analysis to reflect the maximal therapeutic effect, enhance comparability across trials, and avoid unit-of-analysis errors associated with including multiple arms from the same study

doi: 10.1007/s10741-021-10170-1

Naveed, M., Prez, C., Ahmad, E., Russell, L., Lees, Z., & Maybury, C

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As a result, a decrease in adipose tissue may lead to an indirect improvement in the quality of the muscle