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Excess cytosolic Ca 2+ directly stimulates L-type voltage-gated calcium channels (VGCCs) in uterine smooth muscle, leading to pathological hypercontractility that is clinically expressed as severe dysmenorrhea, a hallmark symptom of endometriosis (EMs)

Its often used in medical and wellness settings to address hormone deficiencies, promote muscle growth, and improve recovery

It is important to recognise that QALY thresholds should consider active case finding in individuals under 35, as steatotic liver disease, including MASH, increasingly affects younger populations

Dehydration can reduce blood flow to the kidneys, potentially leading to acute kidney injury (AKI)

These symptoms can indicate that your body is struggling to process the medication or that an organ like your pancreas or gallbladder is under stress