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Additional NMR data are included in the Source Data file

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Replacement of the GLP-2 middle region (residues 719) that mainly interacts with TM1, TM7 and ECL1 by the corresponding part of GLP-1, almost abolished GLP-2R-mediated cAMP accumulation but fully rescued that induced by GLP-1R (Fig

However, some studies suggest that while LC supplementation raises TMAO levels, it does not necessarily correlate with adverse cardiovascular outcomes in all populations