Cytokeratin 4 Polyclonal Antibody, 100ul Vector Construction Mutations in this gene have

Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis

The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane

Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified

This protein is thought to be a negative regulator of AP-1/ATF transcriptional events

LCP2 and PDGFRB (By similarity)

Cytokeratin 4 Polyclonal Antibody, 100ul Vector Construction Mutations in this gene haveThe protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been