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These phenotypes were not attributed to tamoxifen treatment, as treatment of control mice ( Gclc f/w mice) with tamoxifen failed to cause any weight changes (Fig

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This persistent challenge likely reflects multiple factors including prior metabolic adaptations, changes in body composition, lifestyle factors, and possibly residual metabolic effects not fully corrected by thyroid hormone replacement alone

The impact of exercise on depression: How moving makes your brain and body feel better