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Nonetheless, hypoxia-induced stabilization of HIF is essential for intestinal homeostasis owing to its regulatory role in the transcription of barrier-protective genes, mucin secretion, antimicrobial peptide synthesis, nucleotide signaling, iron metabolism, and metabolic genes including hexokinase, lactate dehydrogenase, pyruvate kinase, aldolase, phosphofructokinase, and phosphoglycerate kinase, among others 73,80

Several dendritic melanocytes were observed in the spinous layer and melanin pigment was present in the cytoplasmic processes interposed with keratinocytes

6 Grades of histopathological NASH features corresponding to animals in Figs

Table 3 presents genes that are upregulated, and Table 4 presents genes that are down regulated