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Step 6: Label and refrigerate Write the date of reconstitution on the vial or on a small piece of tape affixed to it

andstep 2: successively coupling the Gly-resin prepared in step 1 to an amino acid according to the sequence of Semaglutide by sequential coupling

This structural difference explains why side effect timing, severity, and duration vary between the two medications

Semaglutide, a type of GLP-1R agonists with 94% sequence homology to GLP-1 and with an extended half-life of approximately 1 week, has been clinically approved to treat T2DM and is available in subcutaneous and oral dosage form (136, 137)