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Because of its central role in metabolic regulation, the GLP-1 signaling axis has become a major therapeutic target for the treatment of obesity and type 2 diabetes

Sun Y, Liu Y, Dian Y, Zeng F, Deng G, Lei S

As it is part of the G protein-coupled receptor family, it has a wide distribution through the body, predominantly localizing to the cellular membrane (138)

GLP-1 receptor agonist intolerance refers to a situation where side effects become severe enough that a patient cannot continue treatment comfortably

It takes a few minutes and replaces the first in-person office visit

[28] A 2014 meta-analysis found no evidence for increased pancreatic cancer risk in people treated with DPP-4 inhibitors, but owing to the modest amount of data available, the authors were unable to completely exclude possibly increased risk