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In a randomized trial involving SLE patients, significant reduction in NET complexes was observed in individuals with the STAT4 risk allele who received Tofacitinib treatment, while no impact was observed in STAT4 risk allele-negative patients or those in the placebo group (134)

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All original substances are subject to rigorous testing in microbiological laboratories where they are tested for heavy metals, insecticides, pesticides, moulds and radioactivity

excessive urinary oxalate excretion and calcium oxalate saturation was decreased at the end of the trial (Siener 2011)