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Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice

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588 Renal ischemia impairs de novo NAD + biosynthesis via reducing the renal expression of QPRT

While the addition of DCA did not produce a statistically significant improvement in clinical outcomes compared to historical controls, the study confirmed the feasibility of integrating metabolic-targeting agents with conventional therapy in HNSCC and provided a rationale for further investigation in selected patient populations (247)

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Weights of the individual skeletal muscles, including gastrocnemius, tibialis anterior, and flexor digitorum superficialis, were also similar between groups