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Thus, various tumors, including glioma, secondary glioblastoma, and acute myeloid leukemia (AML), harboring heterozygous point mutations in the active sites of IDH1/2 show dramatic increases in the R-2-HG levels 111,113,114,115

Hanigan and Frierson, 1996)

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Further, in Appendix 1 of this proposed rule, we are proposing substantive changes to 43 MIPS quality measures, which can be found in Table Group D and Table Group DD of Appendices of this proposed rule