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While Lilly and Novo Nordisk lead today with high-efficacy peptides and multi-agonists, Pfizers diversified pipeline could allow them to carve out a unique space by the 2030s, especially if their monthly GLP-1 and oral combo strategies deliver on tolerability and efficacy

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Data availability Gene-expression profiling interactive analysis in different cancer types and corresponding normal tissues were deposited at GEPIA based on TCGA and GTEx data ( The authenticity of this article has been validated by uploading the key raw data onto the Research Data Deposit public platform ( with the approval RDD number as RDDB2021319938

For men, testosterone levels start to rise when they enter puberty and increase throughout adolescence and early adulthood

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Enhanced L-lactate production in astrocytes may engage the mechanism of metabolic excitability, maintaining the extracellular pool of L-lactate