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Eur J Endocrinol (2011) 164:58590

Medical and Editorial Standards Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims

Sun et al., 2009), and the remaining structure reveals a unique long-distance electrostatic interaction between the active-site cysteine persulfide anion and the positively charged carbonyl carbon of the inhibitor (3MSTI3MT-3) ( O -alkyl and oxamic hydrazone complexes, AOAA, PAG and oxamic hydrazide are likely to inhibit their target enzymes in an irreversible manner

Fredman E, Tschernichovsky R, Shemesh D, Weinstock-Sabbah M, Azuz RD, Radus R, et al