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Helper T cells (TH1) can play a neuroprotective role during recovery through anti-inflammatory cytokines (IL-4, IL-5, IL-10, IL-13), however, cytotoxic T cells can also contribute toward secondary injury from cytotoxic granules ( Clock mutant mice (Walker et al., 2020), that has been corroborated in an ischemic murine model in which 24 h of exposure to dLAN post stroke increased pro-inflammatory response (TNF-, IL-6, and IL-1) in the ipsilateral cortex that can further amplify secondary damage of the infarct (Weil et al., 2020)

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Through this process, L-carnitine contributes to normal metabolic function and cellular energy balance

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