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Participants also recorded reductions in waist circumference (average 7.1cm loss on 6mg, 8.2cm on 12mg, 10cm on 36mg, compared with 3.1cm loss on placebo), blood pressure (estimated -4.2 and -1mm HG difference between placebo and orforglipron in systolic and diatolic blood pressure, respectively) and cholesterol (-2.1% difference between placebo and orforglipron)

This means that if the vial gets too warm or is left in direct sunlight, the medication inside may not work as well as it should

In today's podcast, we're gonna talk about what's happening metabolically in perimenopause and menopause, and how changing hormones are influencing your metabolic health, and what is happening with visceral adiposity, so the fat that likes to pack around our organs

Growth hormone: May improve with weight loss, though effects are variable

Some people notice a change in their energy levels or skin clarity within a few weeks

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