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It has been reported that Dihydroquercetin (DHQ) inhibited ferritin autophagy and decreased ferrous iron in unstable intracellular iron pools by downregulating microtubule-associated protein 1 A/1B-light chain 3 (LC3) and upregulating ferritin heavy chain 1 (FTH1), as well as nuclear receptor co-activator 4 (NCOA4), in activated HBE cells for silicosis treatment [27]

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Reversely, a knockout of the c-Met increased chemically-mediated HCC initiation but did not affect phenobarbital-induced HCC promotion (Marx-Stoelting et al., 2009)

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