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Experienced users suggest capping dose at 60mcg daily, as doses above that amplify water retention and joint pain without proportional anabolic benefit

Nat Commun 12:6943

The same qualification applies

Branched-chain amino acids exacerbate obesity-related hepatic glucose and lipid metabolic disorders via attenuating Akt2 signaling

If you have a known thyroid condition or are taking levothyroxine, a good rule of thumb is to re-check your labs 6 to 8 weeks after starting semaglutide or following a significant weight change