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In addition, more companies are entering the market and expanding availability

NICE guidelines for type 2 diabetes (NG28) and obesity do not include berberine in treatment algorithms

Notably, zero percent of respondents cover GLP-1 drugs for weight loss alone

These include semaglutide (Wegovy) and liraglutide (Saxenda), along with newer combination agents like tirzepatide (Zepbound), which targets both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors

This prolonged gastric retention can increase intragastric pressure and potentially promote the reflux of stomach contents into the oesophagus, leading to symptoms of heartburn, regurgitation, and discomfort