IDH-C227 - IDH1 Inhibitor. CAS# 1355324-14-9 60276 (2013) Nat Chem Biol
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IDH-C227 - IDH1 Inhibitor. CAS# 1355324-14-9 60276 (2013) Nat Chem BiolIDH C227, CAS No. 1355324 14 9, is a potent and selective IDH1 R132H inhibitor first reported in patent WO2012009678. It can inhibit the enzymatic activity of IDH1 R132H in vitro with an IC50 < 0. 1 M, and 2 HG production in HT1080 and U87MG cells with IC50 < 0. 25 M. Because the mutated form of IDH1 produces the metabolite, 2 hydroxyglutarate (2HG), which may contribute to the formation and malignant progression of gliomas as well as other forms of
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