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This disparity can be dramatic

Nasal mucosa is richly vascularized, allowing peptide absorption that bypasses first-pass hepatic metabolism

Vitamin B12 is a water-soluble nutrient essential for red blood cell production, DNA synthesis, and energy metabolism

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Systemic allergic reactions , whilst less common, may manifest as: Widespread urticaria (hives) raised, itchy welts that can appear anywhere on the body Generalised pruritus (itching) without visible rash Maculopapular rash flat red areas with small raised bumps Angioedema deeper swelling, particularly around the face, lips, or throat It is important to distinguish between common injection site reactions and genuine allergic responses