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IKK Gamma Polyclonal Antibody, 100ul[BT-AP04426] Liquid Handling &Storage Studies of similar proteins in

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IKK Gamma Polyclonal Antibody, 100ul[BT-AP04426] Liquid Handling &Storage Studies of similar proteins inIKBKG encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.

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Description

Studies of similar proteins in mouse and rat have indicated a potential role in cellular differentiation

AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH| MIM 113508) when phosphorylated (Kovacina et al

Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain

Cadherins play a role in development

There are three inhibitory families in the superfamily| including the type 1 cystatins (stefins)| type 2 cystatins and the kininogens

IKK Gamma Polyclonal Antibody, 100ul[BT-AP04426] Liquid Handling &Storage Studies of similar proteins inIKBKG encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.

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