Raf-1 Polyclonal Antibody, 100ul[BT-AP13533] Polyclonal Antibodies These variants encode different isoforms|

These variants encode different isoforms| which are differentially expressed and have different kinase activities

The growth factor receptor bound protein 2 encoded by GRB2 binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains

Contains 1 CCHC-type zinc finger

This domain is found in proteins encoded by the TCEAL elongation factor (transcription elongation factor A (SII)-like) gene family also located on the X chromosome

Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure

Raf-1 Polyclonal Antibody, 100ul[BT-AP13533] Polyclonal Antibodies These variants encode different isoforms|This gene is the cellular homolog of viral raf gene (v raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine threonine specific protein kinases, ERK1 and ERK2.