PDK1(Phospho Ser241) Polyclonal Antibody, 20ul Protein Post-translational Modification Mutations in the gene cause

Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia

This gene contains sequences homologous to several motifs that are shared among some nuclear genes encoding mitochondrial proteins and thus may be essential for the coordinated activation of these genes during mitochondrial biogenesis

RNA polymerase III subunit A encoded by POLR3A is the catalytic component of RNA polymerase III

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The cytogenetic location of this locus has been reported as both 8p11 and 8q11

PDK1(Phospho Ser241) Polyclonal Antibody, 20ul Protein Post-translational Modification Mutations in the gene causeCatalytic activity: ATP + a protein = ADP + a phosphoprotein.,Phosphorylates and activates not only PKB AKT, but also PKA, PKC zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.,PTM: Phosphorylated on tyrosine and serine threonine. Phosphorylation on Ser 241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser 241,