PLB Polyclonal Antibody, 100ul Immunology Pseudogenes of this gene have

Pseudogenes of this gene have been defined on chromosomes 14 and 17

The protein encoded by this gene contains a PHD-finger-like domain that is flanked by highly basic N- and C-termini

possibly acting as the signal that turns on the membrane fusion machinery

when complexed to CAK

It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region

PLB Polyclonal Antibody, 100ul Immunology Pseudogenes of this gene haveThe protein encoded by PLN (phospholamban)is found as a pentamer and is a major substrate for the cAMP dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+) ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the