Krs-1/2 Polyclonal Antibody, 50ul RNA Synthesis Freeman-Sheldon syndrome and Sheldon-Hall syndrome

Freeman-Sheldon syndrome and Sheldon-Hall syndrome

Binds to and inhibits cyclin-dependent kinase activity| preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression

and is involved in IL-31 signaling via activation of STAT-3 and STAT-5

Related pseudogenes have been found on chromosomes 3 and 14

This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection

Krs-1/2 Polyclonal Antibody, 50ul RNA Synthesis Freeman-Sheldon syndrome and Sheldon-Hall syndromeSTK3 (serine threonine kinase 3) encodes a serine threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C terminal portion. The N terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants