CEP55(Phospho Ser425) Polyclonal Antibody, 20ul miRNA / siRNA Synthesis the Sec7 domain contains guanine-nucleotide

the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity

The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme

and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface

Alternative splicing of this gene results in several transcript variants encoding different isoforms

where it too functions as an active component of a multifunctional E3 complex

CEP55(Phospho Ser425) Polyclonal Antibody, 20ul miRNA / siRNA Synthesis the Sec7 domain contains guanine-nucleotidePlays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis.,PTM: There is a hierachy of phosphorylation, where both Ser 425 and Ser 428 are phosphorylated at the onset of mitosis, prior to Ser 436. Phosphorylation at Ser 425 and Ser 428 is required for dissociation from the centrosome at the G2 M boundary. Phosphorylation at the 3 sites, Ser 425, Ser 428 and Ser 436,