Rat Acetyl-CoA Acetyltransferase, Cytosolic, ACAT2 ELISA Kit, 96T Molecular Sciences Mediator is recruited to promoters

Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors

Upon binding| this complex translocates to the cytoplasm| where it interacts with TGF-beta receptor type-1 (TGFBR1)| leading to the degradation of both the encoded protein and TGFBR1

Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets

also known as Osler-Rendu-Weber syndrome 1

In the literature it is also referred to as beta4GalT2

Rat Acetyl-CoA Acetyltransferase, Cytosolic, ACAT2 ELISA Kit, 96T Molecular Sciences Mediator is recruited to promoters