RN123 Polyclonal Antibody, 50ul Antibody Development This endoplasmic reticulum protein is

This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids

It also plays a role in the WNT and PI3K signaling pathways

May regulate osteoblast proliferation and differentiation

and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27

Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex

RN123 Polyclonal Antibody, 50ul Antibody Development This endoplasmic reticulum protein isThe protein encoded by this gene contains a C terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein protein and protein DNA interactions, and an N terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants.