Smad7 (Acetyl Lys70) Rabbit Polyclonal Antibody, 50ul Cell Culture Dishes The protein encoded by PAK2

The protein encoded by PAK2 is activated by proteolytic cleavage during caspase-mediated apoptosis

Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2)

and thus mediates immediate-early gene expression in response to various cell stimuli

The product of this gene binds to chemokine receptors CCR4 and CCR8

The protein encoded by this gene is highly similar to S

Smad7 (Acetyl Lys70) Rabbit Polyclonal Antibody, 50ul Cell Culture Dishes The protein encoded by PAK2The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding this complex translocates to the cytoplasm where it interacts with TGF beta receptor type 1 (TGFBR1) leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding