BAG2 Polyclonal Antibody, 100ul Digital Burette The protein encoded by this

The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases

A second ligand| the heditary hemochromatosis protein HFE| competes for binding with transferrin for an overlapping C-terminal binding site

Mutations in this gene also cause familial exudative vitreoretinopathy

Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network

There are three inhibitory families in the superfamily| including the type 1 cystatins (stefins)| type 2 cystatins and the kininogens

BAG2 Polyclonal Antibody, 100ul Digital Burette The protein encoded by thisBAG proteins compete with Hip for binding to the Hsc70 Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45 amino acid BAG domain near the C terminus but differ markedly in their N terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high