SAE1 Polyclonal Antibody, 100ul Metabolic enzymes Sumoylation inhibits the AP-1 transcriptional

Sumoylation inhibits the AP-1 transcriptional activity and is| itself| inhibited by Ras-activated phosphorylation on Thr-232

This gene is a putative tumor suppressor

and sequence variants of this gene are also associated with atrial fibrillation

The encoded protein plays a role in coordinating microtubule attachment by promoting recruitment of dynein proteins

The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways

SAE1 Polyclonal Antibody, 100ul Metabolic enzymes Sumoylation inhibits the AP-1 transcriptionalPosttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO activating enzyme for the sumoylation of proteins.