BubR1 Polyclonal Antibody, 100ul 3D Culture This gene encodes a member

This gene encodes a member of the low density lipoprotein (LDL) receptor family

Mutations at this locus have been associated with lethal congenital contractural syndrome

reducing cell damage

The encoded protein is a calcium-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunits (DNA-PKcs)

and proposed to regulate cell-cycle progression during spermatogenesis

BubR1 Polyclonal Antibody, 100ul 3D Culture This gene encodes a memberBUB1B encodes a kinase involved in spindle checkpoint function. The protein (BUB1 mitotic checkpoint serine threonine kinase B)has been localized to the kinetochore and plays a role in the inhibition of the anaphase promoting complex cyclosome (APC C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.