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Additionally, it triggers transcription through noncanonical pathways, including p38 mitogen-activated protein kinase (p38 MAPK), extracellular regulated protein kinases (ERK), transforming growth factor--activated kinase 1 (TAK1), c-Jun N-terminal kinase (JNK), and Ras homolog family member A (RhoA) GTPase[65]

That pathway helps tag certain experiences and substances as particularly rewarding and worth pursuing again

It was further shown that in some cases, including a large percentage of human non-small cell lung cancers, AKT activity can be low despite loss of PTEN

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5.1.2 Revised International Autoimmune Hepatitis Group 1999 criteria may be used for diagnosis of suspected pediatric autoimmune hepatitis presenting with severe acute presentation, including acute liver failure (LOE 3, Weak recommendation)