MEK Kinase-1 Polyclonal Antibody, 20ul[BT-AP05333] Site-directed Mutagenesis Heterozygous mutations in the this

Heterozygous mutations in the this gene cause auditory-pigmentary syndromes

including a specific mutation that changes an ATG start codon to AGG

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Component of the little elongation complex (LEC)

resulting in the inhibition of TRAF6 NF-kappa-B activation

MEK Kinase-1 Polyclonal Antibody, 20ul[BT-AP05333] Site-directed Mutagenesis Heterozygous mutations in the thisThe protein encoded by MAP3K1 (mitogen activated protein kinase kinase kinase 1) is a serine threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF kappa B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N