NCoA-5 Polyclonal Antibody, 100ul Apoptosis & Autophagy Certain mutations in this gene

Certain mutations in this gene are known to cause distinct forms of muscular dystrophy

Two alternatively spliced transcript variants

The transcription factor SOX-17 may act as a transcriptional regulator after forming a protein complex with other proteins

Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter

p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3'| located in the enhancer region of genes involved in immune response and acute phase reactions

NCoA-5 Polyclonal Antibody, 100ul Apoptosis & Autophagy Certain mutations in this geneNCOA5 (nuclear receptor coactivator 5) encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this