USP40 Polyclonal Antibody, 50ul Roller Bottles This gene encodes the small

This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers

Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons

The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination

also gamma I has an allelic variant gamma II

a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex

USP40 Polyclonal Antibody, 50ul Roller Bottles This gene encodes the smallModification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin conjugating and deubiquitinating enzymes. USP40 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes.