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Sgo1 Polyclonal Antibody, 100ul Fluorescent Staining Abnormal expression of VWA5A may

SKU: 64163753395

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Sgo1 Polyclonal Antibody, 100ul Fluorescent Staining Abnormal expression of VWA5A mayShugoshin like 1 encoded by SGOL1 is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found

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Description

Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin

MIM 611054) for background on liprins

Alternate splice variants have been described but their full length sequences have not been determined

and it can interact with the E2 ubiquitin-conjugating enzyme UbcH5B

RUNX proteins form a heterodimeric complex with CBFβ which confers increased DNA binding and stability to the complex

Sgo1 Polyclonal Antibody, 100ul Fluorescent Staining Abnormal expression of VWA5A mayShugoshin like 1 encoded by SGOL1 is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found

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