PERK Monoclonal Antibody, 100ul In vitro Assessment This metastasis suppressor gene product

This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily

Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway

Represses the transcription of a number of genes including gastrin and ornithine decarboxylase

The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis

The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D

PERK Monoclonal Antibody, 100ul In vitro Assessment This metastasis suppressor gene productThe protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in