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ET-1 Polyclonal Antibody, 100ul Cell Biology The enzyme has steroid 18-hydroxylase

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ET-1 Polyclonal Antibody, 100ul Cell Biology The enzyme has steroid 18-hydroxylaseEDN1 encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants.

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Description

The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity

and other APC complex proteins

Mutations in this gene have been associated with geroderma osteodysplastica

The protein encoded by VAMP4 (vesicle associated membrane protein 4) is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family

IL4I1 encodes interleukin 4 induced 1 with limited similarity to L-amino acid oxidase which contains the conserved amino acids thought to be involved in catalysis and binding of flavin adenine dinucleotide (FAD) cofactor

ET-1 Polyclonal Antibody, 100ul Cell Biology The enzyme has steroid 18-hydroxylaseEDN1 encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants.

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