EGF Receptor(Phospho-Tyr845) Rabbit Polyclonal Antibody, 20ul Vacuum Filter Mutations in this gene have

Mutations in this gene have been associated with pontocerebellar hypoplasia type 2

Nephrocystin-4 interacts with nephrocystin

and has been shown to be a receptor for interleukin 22 (IL22)

This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5

Alternative splicing of this gene results in two transcript variants encoding different isoforms

EGF Receptor(Phospho-Tyr845) Rabbit Polyclonal Antibody, 20ul Vacuum Filter Mutations in this gene haveThe protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.