MLK3(Phospho Thr277+Ser281) Rabbit Polyclonal Antibody, 100ul Cell Screening and Imaging Mutations in this gene result

Mutations in this gene result in autosomal recessive spastic paraplegia

The protein encoded by this gene is an RNA lariat debranching enzyme that hydrolyzes 2'-5' prime branched phosphodiester bonds

SOX6 (SRY-box 6) encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA

Multidrug resistance-associated protein 7 (ATP binding cassette subfamily C member 10) encoded by ABCC10 is a member of the superfamily of ATP-binding cassette (ABC) transporters

Gene Ontology (GO) annotations related to this gene include chromatin binding and nucleosome binding

MLK3(Phospho Thr277+Ser281) Rabbit Polyclonal Antibody, 100ul Cell Screening and Imaging Mutations in this gene resultThe protein encoded by this gene is a member of the serine threonine kinase family. This kinase contains a SH3 domain and a leucine zipper basic motif. This kinase preferentially activates MAPK8 JNK kinase and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate and activates IkappaB kinase alpha and beta and is found to be involved in the transcription activity of NF kappaB mediated by Rho family GTPases