Nibrin(Phospho Ser278) Polyclonal Antibody, 50ul Human Genome Knockout Libraries two TUDOR domains

two TUDOR domains

Members of this family of proteins are associated with complex assembly| protein folding| and export

The encoded protein has an EGF-like calcium binding domain and a seven transmembrane domain in the N-terminal region of the protein

The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways

beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster

Nibrin(Phospho Ser278) Polyclonal Antibody, 50ul Human Genome Knockout Libraries two TUDOR domainsMutations in this gene are associated with Nijmegen breakage syndrome an autosomal recessive chromosomal instability syndrome characterized by microcephaly growth retardation immunodeficiency and cancer predisposition. The encoded protein is a member of the MRE11 RAD50 double strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double strand break repair and DNA damage induced checkpoint