COMP Rabbit Polyclonal Antibody, 50ul Dialysis The tumor protein p53 responds

The tumor protein p53 responds to diverse cellular stresses to regulate expression of target genes

and many specific SCF substrates have been identified including regulators of cell cycle progression and development

Alternative splice variants have been identified| both encoding the same protein

Mutations in this gene are associated with Keppen-Lubinsky Syndrome| a rare condition characterized by severe developmental delay| facial dysmorphism| and intellectual disability

domains III and V contain several EGF-like repeats

COMP Rabbit Polyclonal Antibody, 50ul Dialysis The tumor protein p53 respondsThe protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits each with EGF like and calcium binding (thrombospondin like) domains. Oligomerization results from formation of a five stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations