YAP Polyclonal Antibody, 20ul[BT-AP09632] sgRNA Library Construction Actinin alpha 3 (gene/pseudogene) is

Actinin alpha 3 (gene/pseudogene) is primarily expressed in skeletal muscle and functions as a structural component of sarcomeric Z line

5-trisphosphate (PIP3) by phosphoinositide-3-kinase

GO annotations related to this gene include metallocarboxypeptidase activity

this protein does not contain a C-terminal PDZ domain-binding motif

An important paralog of this gene is JMJD7-PLA2G4B

YAP Polyclonal Antibody, 20ul[BT-AP09632] sgRNA Library Construction Actinin alpha 3 (gene/pseudogene) isYAP1 encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms.