SOCS-3 Polyclonal Antibody, 100ul Peripheral Blood Separation Tube Mutations in BRCA1 are responsible

Mutations in BRCA1 are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers

double strand DNA break repair and apoptosis

Probable global transcription activator SNF2L2 encoded by SMARCA2 is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila

the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death

thus is potentially associated with higher risk of breast cancer

SOCS-3 Polyclonal Antibody, 100ul Peripheral Blood Separation Tube Mutations in BRCA1 are responsibleThis gene encodes a member of the STAT induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN) gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse